Clinical Significance of HbA1c Assessment
HbA1c values represents the average blood glucose level over the past 8-12 weeks and is used for long-term glycemic control in diabetic individuals. Besides monitoring HbA1c is also recommended by international organizations as WHO and ADA for reliable diagnosis of diabetes. Clinical studies demonstrate, that lowering the HbA1c can help to delay or prevent the incidence of late diabetic complications.
Hemoglobin A1c (HbA1c) is metabolically produced by the reaction of glucose with the N-terminal valine residue of each β-chain of hemoglobin and the subsequent formation of a stable ketoamine.