Clinical Significance of HbA1c Assessment

The HbA1c value correlates with the average blood glucose level over the past 8-12 weeks and is used for long-term glycemic control in diabetic individuals. Besides monitoring HbA1c is also recommended by international organizations as WHO and ADA for reliable diabetes diagnosis. Clinical studies demonstrate that lowering the HbA1c level can help to delay or prevent the incidence of late diabetic complications.

Hemoglobin A1c (HbA1c) is metabolically produced by the reaction of glucose with the N-terminal valine residue of each β-chain of hemoglobin and the subsequent formation of a stable ketoamine.